Pope St. Pius X in 1908 changed the name to the Sacred Congregation of the Holy Office. It received its current name in 1965 with Pope Paul VI. Today, according to Article 48 of the Apostolic Constitution on the Roman Curia, "Pastor Bonus", promulgated by the Holy Father John Paul II on June 28, 1988, «the duty proper to the Congregation for the Doctrine of the Faith is to promote and safeguard the doctrine on the faith and morals throughout the Catholic world: for this reason everything which in any way touches such matter falls within its competence.»

The congregation is now headed by Prefect Cardinal William Joseph Levada. It has a Secretary, His Excellency Msgr. Angelo Amato, S.D.B., an under-secretary, Fr. Joseph Augustine Di Noia, O.P., a Promotor of Justice Msgr. Charles Scicluna, and a staff of 37, according to the "Annuario Pontificio" or "Pontifical Yearbook." It also has 23 members - cardinals, archbishops and bishops - and 33 consulters. Given the nature of its task, congregation work is divided into four distinct sections: the doctrinal office, the disciplinary office, the matrimonial office and that for priests.

The congregation, says the "Activity of the Holy See," in conformity with its raison d'ętre, promotes in a collegial fashion encounters and initiatives to «spread sound doctrine and defend those points of Christian tradition which seem in danger because of new and unacceptable doctrines.»

For several years the congregation, together with the Vatican Publishing House, has been issuing volumes containing the texts of its single documents, as well as articles relative to its work which appear in the daily edition of "L'Osservatore Romano". Annually, it holds plenary assemblies.

When bishops are in Rome for their quinquennial "ad limina" visit, they call on the Congregation for the Doctrine of the Faith, as they do with other dicasteries of the Roman Curia, «for an exchange of information and reciprocal concerns.»

There is also ample collaboration between the Pontifical Biblical Commission and the International Theological Commission. each of which has as president the Archbishop Prefect of Doctrine of the Faith. Weekly congregation meetings are held, usually on Wednesday, and are attended by officials and consultors.